丁酰-CoA的β氧化为乙酰-CoA
中文名称
通路描述
β-氧化螺旋的第七次和最终通过以饱和脂肪酸丁酰-CoA为起点，在第三步产生乙酰乙酰-CoA，可生成2分子乙酰-CoA或转向酮体合成途径。需要四个酶促步骤，首先由短链酰-CoA脱氢酶（SCAD）活性开始，随后由crotonase的烯酰-CoA水合酶活性，由短链3-羟基酰-CoA脱氢酶（SCHAD）的3-羟基酰-CoA脱氢酶活性。最后一步产生两分子乙酰-CoA需要特定的酮酰-CoA硫酶，即乙酰乙酰-CoA硫酶。
英文描述
Beta oxidation of butanoyl-CoA to acetyl-CoA The seventh and final pass through the beta-oxidation spiral picks up where the last left off with the saturated fatty acid butanoyl-CoA and at the third step produces acetoacetyl-CoA, which can be used to generate 2 acetyl-CoA molecules or can be turned toward the synthesis of ketone bodies pathway. Four enzymatic steps are required starting with SCAD CoA dehydrogenase (Short Chain) activity, followed by the enoyl-CoA hydratase activity of crotonase, the 3-hydroxyacyl-CoA dehydrogenase activity of the short chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD). The final enzymatic step, creating two acetyl-CoA molecules requires a specific ketoacyl-CoA thiolase, Acetoacetyl-CoA thiolase.
所含基因
5 个基因