IFNG 信号传导调节
中文名称
通路描述
至少存在三类不同的负调节因子来控制 INFG 刺激和信号传导的程度。这些包括属于细胞因子信号抑制蛋白家族的反馈抑制剂、SH2 结构域包含的蛋白酪氨酸磷酸酶（SHPs）以及激活 STAT 的蛋白抑制剂（PIAS）。这些调节因子的诱导似乎能够通过抑制 IFNG 级联中的各种步骤来阻止进一步的信号传导。
英文描述
Regulation of IFNG signaling At least three different classes of negative regulators exist to control the extent of INFG stimulation and signaling. These include the feedback inhibitors belonging to protein family suppressors of cytokine signaling (SOCS), the Scr-homology 2 (SH2)-containing protein tyrosine phosphatases (SHPs), and the protein inhibitors of activated STATs (PIAS). The induction of these regulators seems to be able to stop further signal transduction by inhibiting various steps in IFNG cascade.
所含基因
12 个基因