胃泌素-PKC和MAPK信号通路
中文名称
通路描述
胃泌素是一种激素，其主要功能是刺激胃黏膜分泌盐酸，导致胃泌素形成抑制。该激素还是胃肠道上皮细胞的促有丝分裂因子。胃泌素有两种生物活性肽形式，G34和G17。胃泌素基因表达在各种前癌性条件和已建立癌症中上调，通过多种机制。根据其在组织中表达的水平，多肽产物的差异加工导致产生不同的生物活性肽。随后，这些肽通过经典的胃泌素胆囊收缩素B受体CCK-BR及其异构体和替代受体，触发信号通路，影响影响细胞存活、血管生成和侵袭的下游基因表达（Wank 1995, de Weerth et al. 1999, Grabowska & Watson 2007）。
英文描述
Gastrin-CREB signalling pathway via PKC and MAPK Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17.Gastrin gene expression is upregulated in both a number of pre-malignant conditions and in established cancer through a variety of mechanisms. Depending on the tissue where it is expressed and the level of expression, differential processing of the polypeptide product leads to the production of different biologically active peptides. In turn, acting through the classical gastrin cholecystokinin B receptor CCK-BR, its isoforms and alternative receptors, these peptides trigger signalling pathways which influence the expression of downstream genes that affect cell survival, angiogenesis and invasion (Wank 1995, de Weerth et al. 1999, Grabowska & Watson 2007)
所含基因
9 个基因