核内PIP的合成
中文名称
通路描述
在细胞应激条件下，核内磷脂酰肌醇-5-磷酸（PI5P）水平增加。类型I磷脂酰肌醇4,5-双磷酸4-磷酸酶TMEM55B在应激下通过未知机制转运至核内，从PI(4,5)P2底物生成PI5P。核内PI5P水平保持低水平，这是由于核内PIP4K2二聚体的磷脂酰肌醇-5-磷酸4-激酶活性，主要是包含PIP4K2B的二聚体（Ciruela et al. 2000）。在细胞应激条件下，核内PIP4K2B被p38 MAP家族激酶磷酸化和失活（Jones et al. 2006）。
英文描述
Synthesis of PIPs in the nucleus Under conditions of cellular stress, nuclear levels of phosphatidylinositol-5-phosphate (PI5P) increase. Type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase TMEM55B translocates to the nucleus under stress via an unknown mechanism (Zou et al. 2007) and generates PI5P from the PI(4,5)P2 substrate. The level of PI5P in the nucleus is kept low because of the phosphatidylinositol-5-phosphate 4-kinase activity of nuclear PIP4K2 dimers, mainly dimers containing PIP4K2B (Ciruela et al. 2000). Under conditions of cellular stress, nuclear PIP4K2B is phosphorylated and inactivated by p38 MAP family kinases (Jones et al. 2006).
所含基因
4 个基因