ERBB2激活PTK6信号
中文名称
通路描述
PTK6（BRK）在ERBB2（HER）和其他受体酪氨酸激酶如EGFR（Kamalati et al. 1996）和MET（Castro和Lange 2010）下游被激活。然而，不清楚MET和EGFR是否直接激活PTK6，还是通过ERBB2起作用，因为已知ERBB2与EGFR形成异二聚体（Spivak-Kroizman et al. 1992），而MET可以与EGFR和ERBB2异二聚化（Tanizaki et al. 2011）。
英文描述
ERBB2 Activates PTK6 Signaling PTK6 (BRK) is activated downstream of ERBB2 (HER) (Xiang et al. 2008, Peng et al. 2015) and other receptor tyrosine kinases, such as EGFR (Kamalati et al. 1996) and MET (Castro and Lange 2010). However, it is not clear if MET and EGFR activate PTK6 directly or act through ERBB2, since it is known that ERBB2 forms heterodimers with EGFR (Spivak-Kroizman et al. 1992), and MET can heterodimerize with both EGFR and ERBB2 (Tanizaki et al. 2011).
所含基因
11 个基因