TLR3 介导的 TICAM1 依赖性程序性细胞死亡
中文名称
通路描述
TLR3 和 TLR4 触发 TRIF(TICAM1)-依赖性程序性细胞死亡，见于多种人和小鼠细胞。凋亡是程序性细胞死亡的一种常见形式，由一系列 caspase 的激活介导。除了凋亡外，TLR3/TLR4 激活还诱导 RIP3 依赖性坏死性凋亡。这两种程序性细胞死亡途径可能相互抑制。当 caspase 活性受损或受抑制时，某些细胞类型会响应各种刺激（如 TNF、Fas、病毒感染和其他应激刺激）将凋亡死亡程序切换为坏死性凋亡（Kalai M et al. 2002; Weber A et al. 2010; Feoktistova M et al. 2011, Tenev et al 2011）。
英文描述
Threonine catabolism In many mammals, threonine can be catabolized either via mitochondrial L-threonine 3-dehydrogenase (TDH) to yield acetyl-CoA and glycine (Dale 1978; Tressel et al. 1986) or via cytosolic L-serine dehydratase/L-threonine deaminase (SDS and the related SDSL (SDS-like) protein) to yield 2-oxobutanoate. Data from rat liver suggests that usage of the two pathways varies with physiological state (Bird & Nunn 1983). Studies of healthy human subjects suggest that almost all threonine catabolism follows the 2-oxobutanoate pathway (Darling et al. 2000) consistent with the finding that the human genomic TDH gene appears to encode a product that would be mis-spliced and catalytically inactive (Edgar 2002). Human threonine degradation is therefore annotated here as the conversion of threonine to 2-oxobutanoate and the related conversion of 2-iminobutanoate to 2-oxobutanoate.
所含基因
3 个基因