线粒体生物发生转录激活
中文名称
通路描述
磷酸化的PPARGC1A（PGC-1α）不直接结合DNA，而是与其他转录因子相互作用，特别是NRF1和NRF2（通过HCF1）。NRF1和NRF2与PPARGC1A共同激活核编码、线粒体靶向蛋白的转录，如TFB2M、TFB1M和TFAM。PGC-1β和PPRC似乎与PGC-1α类似，但研究较少。PPARGC1A的转录由CREB1（钙反应）、MEF2C/D、ATF2和PPARGC1A上调。PPARGC1A的转录由NR1D1（REV-ERBA）抑制。
英文描述
Signaling by FGFR2 IIIa TM A soluble truncated form of FGFR2 is aberrantly expressed in an Apert Syndrome mouse model and inhibits FGFR signaling in vitro and in vivo. This variant, termed FGFR IIIa TM, arises from an misspliced transcript that fuses exon 7 to exon 10 and that escapes nonsense-mediated decay. FGFR2 IIIa TM may inhibit signaling by sequestering FGF ligand and/or by forming nonfunctional heterodimers with full-length receptors at the cell surface (Wheldon et al, 2011).
所含基因
18 个基因