RA 生物合成通路
中文名称
通路描述
主要激活的视黄醛，全反式视黄酸（atRA）是由短链脱氢酶/还原酶（SDR）和醛脱氢酶（RALDH）基因家族的成员，通过全反式视黄醇（atROL）的脱氢反应产生的。
英文描述
Interaction between PHLDA1 and AURKA PHLDA1 (TDAG51), the product of a gene involved in breast cancer progression, interacts with aurora kinase A (AURKA). While unphosphorylated PHLDA1 promotes AURKA ubiquitination and degradation, AURKA-mediated phosphorylation of PHLDA1 results in down-regulation of PHLDA1 protein levels. Ectopic expression of PHLDA1 strongly antagonizes AURKA-triggered oncogenic phenotypes, suggesting PHLDA1 downregulation as one of the key mechanisms by which AURKA promotes breast cancer (Johnson et al. 2011).
所含基因
2 个基因