线粒体翻译终止
中文名称
通路描述
当 MTRF1L (MTRF1a) 识别 mRNA 上的 UAA 或 UAG 终止密码子时，翻译在核糖体 A 位点终止。MT-CO1 和 MT-ND6 蛋白的翻译分别在 AGG 和 AGA 密码子处终止。这两个非标准终止密码子被 MTRF1 识别。GTP 被水解，39S 核糖体亚基水解翻译多肽链与 P 位最终 tRNA 之间的氨基酰键，释放多肽链。随后，MRRF (RRF) 和 GFM2:GTP (EF-G2mt:GTP) 释放剩余 tRNA 和 mRNA，使 55S 核糖体解离为 28S 和 39S 亚基。
英文描述
Interleukin-20 family signaling The interleukin 20 (IL20) subfamily comprises IL19, IL20, IL22, IL24 and IL26. They are members of the larger IL10 family, but have been grouped together based on their usage of common receptor subunits and similarities in their target cell profiles and biological functions. Members of the IL20 subfamily facilitate the communication between leukocytes and epithelial cells, thereby enhancing innate defence mechanisms and tissue repair processes at epithelial surfaces. Much of the understanding of this group of cytokines is based on IL22, which is the most studied member (Rutz et al. 2014, Akdis M et al. 2016, Longsdon et al. 2012).
所含基因
25 个基因