极低密度脂蛋白组装
中文名称
通路描述
极低密度脂蛋白（VLDL）在肝脏中通过两步合成。首先，在粗面内质网腔中，apoB-100 经过共翻译和翻译后修饰进行脂化。转移到光滑内质网腔后，脂化的 apoB-100 获得脂质成为真正的 VLDL。VLDL 的脂质组成包括：甘油三酯（50-60%）、胆固醇（10-12%）、胆固醇酯（4-6%）、磷脂（18-20%）和 apoB（8-12%）。当 VLDL 组装完成后，它沿着高尔基复合体移动，最终从肝脏分泌到一般循环中。在循环中，VLDL 可以获取更多的脂蛋白。至少还有两种其他脂蛋白成分；apoC-I（APOC1，约占 20%）和 apoC4（APOC4，少量）（Gibbons et al. 2004; Olofsson et al. 2000）。
英文描述
VLDL assembly Very low-density lipoprotein (VLDL) is synthesised in the liver in two steps. First, apolipoprotein B-100 (APOB-100) is co- and post-translationally lipidated in the rough ER lumen. After transfer to the smooth ER lumen, lipidated APOB-100 acquires lipids to become bona fide VLDL. Lipid composition of VLDL - triglycerides (50-60%), cholesterol (10-12%), cholesterol esters (4-6%), phospholipids (18-20%), and apolipoprotein B (8-12%). When VLDL assembly is complete, it travels along the Golgi apparatus to be eventually secreted from the liver into general circulation. In circulation, VLDL can acquire more lipoproteins. At least two other apolipoproteins are constituents; apolipoprotein C-I (APOC1, around 20%) and apolipoprotein C4 (APOC4, minor amount) (Gibbons et al. 2004; Olofsson et al. 2000).
所含基因
5 个基因