TFAP2（AP-2）家族转录因子的活性负调控
中文名称
通路描述
TFAP2（AP-2）转录因子家族同源二聚体和异二聚体的转录活性受 KCTD1 或 KCTD15 与 AP-2 转录激活域结合而抑制（Ding et al. 2009, Zarelli and Dawid 2013）。TFAP2A、TFAP2B 和 TFAP2C 的转录活性也受 UBE2I（UBC9）介导的 SUMO 化负调控（Eloranta and Hurst 2002, Berlato et al. 2011, Impens et al. 2014, Bogachek et al. 2014）。肿瘤抑制因子 WWOX 与 TFAP2C 的结合抑制 TFAP2C 向细胞核的转位（Aqeilan et al. 2004）。TFAP2A 基因的转录可能受 CREB 和 E2F1 抑制（Melnikova et al. 2010）。
英文描述
Negative regulation of activity of TFAP2 (AP-2) family transcription factors Transcriptional activity of TFAP2 (AP-2) transcription factor family homo- and heterodimers in inhibited by binding of KCTD1 or KCTD15 to the AP-2 transactivation domain (Ding et al. 2009, Zarelli and Dawid 2013). Transcriptional activity of TFAP2A, TFAP2B and TFAP2C is also negatively regulated by SUMOylation mediated by UBE2I (UBC9) (Eloranta and Hurst 2002, Berlato et al. 2011, Impens et al. 2014, Bogachek et al. 2014). Binding of the tumor suppressor WWOX to TFAP2C inhibits TFAP2C translocation to the nucleus (Aqeilan et al. 2004). Transcription of the TFAP2A gene may be inhibited by CREB and E2F1 (Melnikova et al. 2010).
所含基因
11 个基因