TFAP2 (AP-2) 转录因子的激活
中文名称
通路描述
TFAP2 (AP-2) 转录因子家族的激活。TFAP2 (AP-2) 转录因子家族成员 TFAP2A、TFAP2B、TFAP2C、TFAP2D 和 TFAP2E 的螺旋 - 跨 - 螺旋基序和碱性区域使二聚化和 DNA 结合成为可能。AP-2 二聚体结合具有反向重复的 GC 富集 DNA 响应元件，这些元件与共识序列 5'-GCCNNNGGC-3'相匹配 (Williams and Tjian 1991a, Williams and Tjian 1991b)。大多数 AP-2 结合位点与共识序列略有不同，AP-2 家族成员可能在结合位点偏好上有所不同 (McPherson and Weigel 1999, Orso et al. 2010)。来自 CITED 家族的转录共调节因子与 TFAP2 (AP-2) 转录因子家族的螺旋 - 跨 - 螺旋 (HSH) 结构域相互作用，招募转录共激活因子 EP300 (p300) 和 CREBBP (CBP) 到 TFAP2 结合的 DNA 元件上。CITED2 对 TFAP2 蛋白的亲和力最高，其次是 CITED4，而 CITED1 与 TFAP2 的结合亲和力极低。缺乏 CITED2 的胚胎表现出神经嵴缺陷、心脏畸形和肾上腺缺失，这至少部分归因于 Tfap2 转录激活缺陷 (Bamforth et al. 2001, Braganca et al. 2002, Braganca et al. 2003)。TFAP2B 同源二聚体的 DNA 结合和转录活性通过与 YEATS4 (GAS41) 结合而增加 (Ding et al. 2006)。
英文描述
Activation of the TFAP2 (AP-2) family of transcription factors The helix-span-helix motif and the basic region of TFAP2 (AP-2) transcription factor family members TFAP2A, TFAP2B, TFAP2C, TFAP2D and TFAP2E enable dimerization and DNA binding. AP-2 dimers bind palindromic GC-rich DNA response elements that match the consensus sequence 5'-GCCNNNGGC-3' (Williams and Tjian 1991a, Williams and Tjian 1991b). Most of the AP-2 binding sites slightly differ from the consensus, and individual AP-2 family members may differ in their binding site preferences (McPherson and Weigel 1999, Orso et al. 2010). Transcriptional co-factors from the CITED family interact with the helix-span-helix (HSH) domain of TFAP2 (AP-2) family of transcription factors and recruit transcription co-activators EP300 (p300) and CREBBP (CBP) to TFAP2-bound DNA elements. CITED2 shows the highest affinity for TFAP2 proteins, followed by CITED4, while CITED1 interacts with TFAP2s with a very low affinity. Mouse embryos defective for CITED2 exhibit neural crest defects, cardiac malformations and adrenal agenesis, which can at least in part be attributed to a defective Tfap2 transactivation (Bamforth et al. 2001, Braganca et al. 2002, Braganca et al. 2003). DNA binding and transcriptional activity of TFAP2B homodimers is increased by binding to YEATS4 (GAS41) (Ding et al. 2006).
所含基因
12 个基因