TFAP2 (AP-2) 家族调控生长因子及其受体的转录
中文名称
通路描述
TFAP2 (AP-2) 家族调控生长因子及其受体的转录。TFAP2A 和 TFAP2C 直接刺激雌激素受体 ESR1 基因的转录 (McPherson and Weigel 1999)。在乳腺癌中，TFAP2A 的表达与 ESR1 的表达呈正相关，而 TFAP2C 在雌激素阳性乳腺癌和子宫内膜癌中经常高表达 (deConinck et al. 1995, Turner et al. 1998)。TFAP2A、TFAP2C 以及 TFAP2B 可以直接刺激 ERBB2 的表达，这是另一个重要的乳腺癌基因 (Bosher et al. 1996)。TFAP2A 与 YY1 转录因子的结合显著增加了 ERBB2 的转录速率 (Begon et al. 2005)。除了 ERBB2 外，TFAP2A 和 TFAP2B 还刺激了另一种受体酪氨酸激酶 KIT 的表达 (Huang et al. 1998)，而 TFAP2A 抑制了 VEGF 受体酪氨酸激酶配体 VEGFA 的表达 (Ruiz et al. 2004, Li et al. 2012)。TFAP2A 刺激了转化生长因子 alpha (TGFA) 基因的转录 (Wang et al. 1997)。TFAP2C 调节了乳管乳腺癌中 EGFR 的表达 (De Andrade et al. 2016)。在胎盘组织中，TFAP2A 和 TFAP2C 直接刺激人类绒毛促性腺激素 (CGA 和 CGB) 两个亚基的转录 (Johnson et al. 1997, LiCalsi et al. 2000)。
英文描述
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors TFAP2A and TFAP2C directly stimulate transcription of the estrogen receptor ESR1 gene (McPherson and Weigel 1999). TFAP2A expression correlates with ESR1 expression in breast cancer, and TFAP2C is frequently overexpressed in estrogen-positive breast cancer and endometrial cancer (deConinck et al. 1995, Turner et al. 1998). TFAP2A, TFAP2C, as well as TFAP2B can directly stimulate the expression of ERBB2, another important breast cancer gene (Bosher et al. 1996). Association of TFAP2A with the YY1 transcription factor significantly increases the ERBB2 transcription rate (Begon et al. 2005). In addition to ERBB2, the expression of another receptor tyrosine kinase, KIT, is also stimulated by TFAP2A and TFAP2B (Huang et al. 1998), while the expression of the VEGF receptor tyrosine kinase ligand VEGFA is repressed by TFAP2A (Ruiz et al. 2004, Li et al. 2012). TFAP2A stimulates transcription of the transforming growth factor alpha (TGFA) gene (Wang et al. 1997). TFAP2C regulates EGFR expression in luminal breast cancer (De Andrade et al. 2016). In placenta, TFAP2A and TFAP2C directly stimulate transcription of both subunits of the human chorionic gonadotropin, CGA and CGB (Johnson et al. 1997, LiCalsi et al. 2000).
所含基因
12 个基因