TFAP2A
中文名称
通路描述
在类固醇诱导的分化过程中，TFAP2A 作为转录抑制因子发挥作用，与 NPM1（核糖核蛋白 M1）复合物一起抑制 HSPD1（热休克蛋白 60）、NOP2（p120）和 MYBL2（b-Myb）的转录。这种基因表达的抑制可能涉及 NPM1 招募组蛋白去乙酰化酶 HDAC1 和 HDCA2 到靶启动子。TFAP2A 和 NPM1 的复合物也可以在 NPM1 启动子处检测到，这与类固醇处理后 NPM1 表达降低一致。TFAP2A 的水平在类固醇处理后增加（Liu 等，2007）。NOP2 和 MYBL2 都是增殖标记物（Valdez 等，1992；Saville 和 Watson，1998）。
英文描述
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation During retinoic acid-induced cell differentiation, TFAP2A, in complex with NPM1 (nucleophosmin), represses transcription of HSPD1 (Hsp60), NOP2 (p120) and MYBL2 (b-Myb). The repression of gene expression probably involves the recruitment of histone deacetylases HDAC1 and HDCA2 to target promoters by NPM1. The complex of TFAP2A and NPM1 can also be detected at the NPM1 promoter, which is in agreement with decreased NPM1 expression after retinoic acid treatment. The level of TFAP2A increases in response to the retinoic acid treatment (Liu et al. 2007). NOP2 and MYBL2 are both proliferation markers (Valdez et al. 1992, Saville and Watson 1998).
所含基因
5 个基因