内耳B介导的链球菌拟杆菌进入宿主细胞
中文名称
通路描述
内耳B是链球菌拟杆菌的细胞壁蛋白，结合MET受体，作为HGF激动剂（Shen et al. 2000, Veiga and Cossart 2005）。链球菌拟杆菌的InlB蛋白通过其富含亮氨酸的重复区域（LRRs）二聚化，促进其结合的MET受体二聚化（Ferraris et al. 2010）。InlB诱导的MET受体二聚化后，发生MET的自磷酸化和下游RAS/RAF/MAPK信号通路以及PI3K/AKT信号通路的激活（Niemann et al. 2007, Ferraris et al. 2010）。内耳B结合的磷酸化MET受体通过GRB2招募E3泛素连接酶CBL。CBL介导的InlB结合的MET的单泛素化促进链球菌拟杆菌进入宿主细胞（Veiga and Cossart 2005）。CBL介导的MET单泛素化诱导的链球菌拟杆菌内吞介导的进入需要CIN85（Veiga and Cossart 2005）。参与氯酪蛋白介导的内吞作用的EPS15和HGS（Hrs）蛋白对于CBL和MET介导的链球菌拟杆菌进入宿主细胞都是必需的（Veiga and Cossart 2005）。CD44作为内耳B介导的MET激活的核心受体的潜在作用存在矛盾（Jung et al. 2009, Dortet et al. 2010）。
英文描述
InlB-mediated entry of Listeria monocytogenes into host cell InlB, a cell wall protein of Listeria monocytogenes, binds MET receptor, acting as an HGF agonist (Shen et al. 2000, Veiga and Cossart 2005). Listeria monocytogenes InlB proteins dimerize through their leucine-rich repeat regions (LRRs), promoting dimerization of MET receptors that they are bound to (Ferraris et al. 2010). InlB-induced MET receptor dimerization is followed by MET trans-autophosphorylation and activation of downstream RAS/RAF/MAPK signaling and PI3K/AKT signaling (Niemann et al. 2007, Ferraris et al. 2010). InlB-bound phosphorylated MET receptor recruits the E3 ubiquitin ligase CBL through GRB2. CBL-mediated monoubiquitination of InlB-bound MET promotes endocytosis and entry of Listeria monocytogenes to host cells (Veiga and Cossart 2005). CIN85 is necessary for endocytosis-mediated entry of Listeria monocytogenes triggered by CBL-mediated monoubiquitination of MET (Veiga and Cossart 2005). Proteins involved in clathrin-mediated endocytosis EPS15 and HGS (Hrs) are both necessary for CBL and MET-mediated entry of Listeria monocytogenes into host cells (Veiga and Cossart 2005).
A potential coreceptor role of CD44 in InlB-mediated MET activation is contradictory (Jung et al. 2009, Dortet et al. 2010).
A potential coreceptor role of CD44 in InlB-mediated MET activation is contradictory (Jung et al. 2009, Dortet et al. 2010).
所含基因
14 个基因