TRIF 介导的程序性细胞死亡
中文名称
通路描述
TLR3 和 -4 触发 TRIF 依赖的程序性细胞死亡，在各种人和小鼠细胞中发生。凋亡是程序性细胞死亡的一种常见形式，由一系列 caspase 的激活介导。除了凋亡外，TLR3/TLR4 激活还诱导 RIP3 依赖的坏死性凋亡。这两种程序性细胞死亡途径可能相互抑制。当 caspase 活性受损或受抑制时，某些细胞类型会响应各种刺激（如 TNF、Fas、病毒感染和其他应激刺激）将凋亡死亡程序切换到坏死性凋亡（Kalai M et al. 2002; Weber A et al. 2010; Feoktistova M et al. 2011, Tenev et al 2011）。
英文描述
MET receptor recycling Activated MET receptor is subject to recycling from the plasma membrane through the endosomal compartment and back to the plasma membrane (Peschard et al. 2001, Hammond et al. 2001, Petrelli et al. 2002). In the recycling process, activated MET receptor is endocytosed, and the GGA3 protein directs it, via a largely unknown mechanism, through the RAB4 positive endosomal compartments back to the plasma membrane (Parachoniak et al. 2011). Endosomal signaling by MET during the recycling process appears to play an important role in sustained activation of ERK1/ERK2 (MAPK3/MAPK1) and STAT3 downstream of MET (Kermorgant and Parker 2008).
所含基因
8 个基因