RUNX1 调节造血干细胞分化相关基因转录

中文名称

通路描述

RUNX1:CBFB 复合物调节 SPI1 (PU.1) 基因的转录，该基因与造血干细胞 (HSCs) 的分化有关。RUNX1 招募组蛋白甲基转移酶 KMT2A (MLL) 到 SPI1 基因座，导致与 SPI1 启动子及上游调控元件相关的核小体上产生激活的 H3K4Me3 标记 (Huang et al. 2011)。SPI1 通过转激活抑制 HSCs 的自我更新和增殖 (Fukuchi et al. 2008)，并且是 HSCs 分化为特定造血谱系所必需的 (Imperato et al. 2015)。作为 TAL1 转录因子复合物的组成部分，参与急性 T 细胞淋巴样白血病 (T-ALL)，RUNX1 可以通过刺激 MYB 基因和可能 TRIB2 基因的转录来促进造血干细胞的生长并抑制其凋亡 (Sanda et al. 2012, Mansour et al. 2014)。

英文描述

RUNX1 regulates transcription of genes involved in differentiation of HSCs The RUNX1:CBFB complex regulates transcription of the SPI1 (PU.1) gene, involved in differentiation of hematopoietic stem cells (HSCs). RUNX1 recruits histone methyltransferase KMT2A (MLL) to the SPI1 gene locus, leading to generation of the activating H3K4Me3 mark on nucleosomes associated with the SPI1 promoter and the upstream regulatory element (Huang et al. 2011). SPI1 transactivation represses self-renewal and proliferation of HSCs (Fukuchi et al. 2008) and is needed for commitment of HSCs to specific hematopoietic lineages (Imperato et al. 2015).
As a component of the TAL1 transcription factor complex, involved in acute T cell lymphoblastic leukemia (T-ALL), RUNX1 can promote growth and inhibit apoptosis of hematopoietic stem cells by stimulating transcription of the MYB gene and possibly the TRIB2 gene (Sanda et al. 2012, Mansour et al. 2014).

所含基因

85 个基因

ABL1 ADRM1 CBFB CCNH CDK7 GATA1 GATA2 GATA3 H2AFB1 H2AFJ H2AFV H2AFX H2BFS H3F3A HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4 HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3A HIST3H2BB ITCH KMT2A LDB1 LMO1 LMO2 MNAT1 MYB PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 RPS27A RUNX1 SEM1 SPI1 TAL1 TCF12 TCF3 TP73 UBA52 UBB UBC YAP1