RUNX1 调节表皮角质形成细胞分化相关基因转录
中文名称
通路描述
RUNX1:CBFB 复合物直接抑制 SERPINB13 基因的转录，该基因与表皮角质形成细胞分化有关，且在头颈部癌症中经常下调 (Boyapati et al. 2011)。RUNX1 还抑制 STAT3 抑制剂 SOCS3 和 SOCS4 的转录，导致 STAT3 活性升高。RUNX1 介导的 STAT3 活性增加，首先在角质形成细胞中被发现，被认为与上皮干细胞维持有关，并促进包括皮肤鳞状细胞癌 (SCC) 在内的上皮癌症的发展 (Scheitz et al. 2012)。
英文描述
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes The RUNX1:CBFB complex directly inhibits transcription of the SERPINB13 gene (Nomura et al. 2005), a gene involved in keratinocyte differentiation that is frequently down-regulated in head and neck cancers (Boyapati et al. 2011). RUNX1 also inhibits transcription of STAT3 inhibitors SOCS3 and SOCS4, resulting in elevated STAT3 activity. RUNX1-mediated increase in STAT3 activity, first discovered in keratinocytes, is thought to be involved in the maintenance of epithelial stem cells and contributes to development of epithelial cancers, including squamous cell carcinoma (SCC) of the skin (Scheitz et al. 2012).
所含基因
8 个基因