RUNX1 与调节 RUNX1 靶标的共因子的相互作用，其确切作用尚不清楚
中文名称
通路描述
RUNX1:CBFB 复合物的转录活性受与 RUNX1 的共因子相互作用及 RUNX1 的翻译后修饰调节。蛋白丝氨酸/苏氨酸激酶 HIPK2 可以磷酸化 RUNX1，并影响 RUNX1:CBFB 复合物的转录活性。白血病中发现的一些 CBFB 突变干扰了 RUNX1 的 HIPK2 介导的磷酸化。HIPK2 可以同时磷酸化 RUNX1 和与 RUNX1:CBFB1 复合物结合的 P300 (EP300) (Aikawa et al. 2006, Wee et al. 2008)。RUNX1:CBFB 复合物可以与组蛋白去乙酰化酶复合体 1 (PRC1) 结合。PRC1 复合物在许多 RUNX1 靶启动子处存在，并在 RUNX1 靶标的转激活中既可以作为共激活子也可以作为共抑制子 (Yu et al. 2011)。RUNX1 通过直接与几个 SWI/SNF 亚基相互作用，招募 SWI/SNF 染色质重塑复合物到许多 RUNX1 靶启动子处 (Bakshi et al. 2010)。RUNX1:CBFB 复合物的其他共因子在特定基因的转录调节背景下被注释。
英文描述
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known The transcriptional activity of the RUNX1:CBFB complex is regulated by interaction with co-factors and posttranslational modifications of RUNX1. Protein serine/threonine kinase HIPK2 can phosphorylate RUNX1 and affect transcriptional activity of the RUNX1:CBFB complex during hematopoiesis. Some CBFB mutations found in leukemia interfere with HIPK2-mediated phosphorylation of RUNX1. HIPK2 can simultaneously phosphorylate RUNX1 and EP300 (p300) bound to the RUNX1:CBFB1 complex (Aikawa et al. 2006, Wee et al. 2008).
The RUNX1:CBFB complex can associate with the polycomb repressor complex 1 (PRC1). PRC1 complexes are found at many RUNX1 target promoters and can act either as co-activators or co-repressors in the transactivation of RUNX1 targets (Yu et al. 2011).
RUNX1 recruits the SWI/SNF chromatin remodeling complex to many RUNX1 target promoters by directly interacting with several SWI/SNF subunits (Bakshi et al. 2010).
Other co-factors of the RUNX1:CBFB complex are annotated in the context of transcriptional regulation of specific genes.
The RUNX1:CBFB complex can associate with the polycomb repressor complex 1 (PRC1). PRC1 complexes are found at many RUNX1 target promoters and can act either as co-activators or co-repressors in the transactivation of RUNX1 targets (Yu et al. 2011).
RUNX1 recruits the SWI/SNF chromatin remodeling complex to many RUNX1 target promoters by directly interacting with several SWI/SNF subunits (Bakshi et al. 2010).
Other co-factors of the RUNX1:CBFB complex are annotated in the context of transcriptional regulation of specific genes.
所含基因
36 个基因