RUNX1 调节髓系细胞分化相关基因转录
中文名称
通路描述
RUNX1:CBFB 复合物调节参与髓系祖细胞分化的基因表达，这些祖细胞可以分化为产生血小板、红细胞、白细胞或单核细胞的造血谱系。RUNX1:CBFB 复合物将组蛋白乙酰转移酶 CREBBP (CBP) 招募到 CSF2 基因的启动子处，编码粒细胞 - 巨噬细胞集落刺激因子 (GM-CSF)，从而诱导 GM-CSF 表达 (Oakford et al. 2010)。GM-CSF 诱导巨噬细胞、粒细胞、红细胞和巨核细胞从髓系祖细胞生长、分化和存活 (Barreda et al. 2004)。RUNX1:CBFB 复合物直接刺激 LGALS3 基因的转录，编码 galectin-3 (Zhang et al. 2009)。Galectin-3 在髓系祖细胞中表达，其水平在成熟过程中增加 (Le Marer 2000)。PRKCB 基因编码调节髓系细胞凋亡的蛋白激酶 C-beta，该基因被 RUNX1:CBFB 复合物直接转激活 (Hu et al. 2004)。
英文描述
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells The RUNX1:CBFB complex regulates expression of genes involved in differentiation of myeloid progenitors which can commit to hematopoietic lineages that lead to generation of platelets, erythrocytes, leukocytes or monocytes.
The RUNX1:CBFB complex recruits histone acetyltransferase CREBBP (CBP) to the promoter of the CSF2 gene, encoding Granulocyte-macrophage colony stimulating factor (GM-CSF), thus inducing GM-CSF expression (Oakford et al. 2010). GM-CSF induces growth, differentiation and survival of macrophages, granulocytes, erythrocytes and megakaryocytes from myeloid progenitors (Barreda et al. 2004).
The RUNX1:CBFB complex directly stimulates transcription of the LGALS3 gene, encoding galectin-3 (Zhang et al. 2009). Galectin-3 is expressed in myeloid progenitors and its levels increase during the maturation process (Le Marer 2000).
The PRKCB gene, encoding protein kinase C-beta, which regulates apoptosis of myeloid cells, is directly transactivated by the RUNX1:CBFB complex (Hu et al. 2004).
The RUNX1:CBFB complex recruits histone acetyltransferase CREBBP (CBP) to the promoter of the CSF2 gene, encoding Granulocyte-macrophage colony stimulating factor (GM-CSF), thus inducing GM-CSF expression (Oakford et al. 2010). GM-CSF induces growth, differentiation and survival of macrophages, granulocytes, erythrocytes and megakaryocytes from myeloid progenitors (Barreda et al. 2004).
The RUNX1:CBFB complex directly stimulates transcription of the LGALS3 gene, encoding galectin-3 (Zhang et al. 2009). Galectin-3 is expressed in myeloid progenitors and its levels increase during the maturation process (Le Marer 2000).
The PRKCB gene, encoding protein kinase C-beta, which regulates apoptosis of myeloid cells, is directly transactivated by the RUNX1:CBFB complex (Hu et al. 2004).
所含基因
8 个基因