RUNX1 调节与白细胞介素信号通路相关的基因转录
中文名称
通路描述
RUNX1:CBFB 复合物调节至少几个与白细胞介素信号通路相关的基因。LIFR 基因是 RUNX1:CBFB 复合物的直接转录靶点，编码白血病抑制因子（LIF）受体，LIF 是白细胞介素 -6 家族成员。LIFR 涉及造血、胚胎植入、胎盘形成和神经系统发育。与协同激活因子 ELF1 结合时，RUNX1:CBFB 复合物刺激 IL3 基因的转录，编码白细胞介素 -3（Mao et al. 1999）。
英文描述
RUNX1 regulates transcription of genes involved in interleukin signaling The RUNX1:CBFB complex regulates transcription of at least a couple of genes involved in interleukin signaling. The LIFR gene, a direct transcriptional target of the RUNX1:CBFB complex (Qadi et al. 2016), encodes the receptor for the leukemia inhibitory factor (LIF), a member of the interleukin-6 family. LIFR is implicated in hematopoiesis, embryo implantation, placental formation and nervous system development (Nicola et al. 2015). In association with its co-activator ELF1, the RUNX1:CBFB complex stimulates transcription of the IL3 gene, encoding interleukin-3 (Mao et al. 1999).
所含基因
5 个基因