RUNX1 调节与 WNT 信号通路相关的基因转录
中文名称
通路描述
RUNX1:CBFB 复合物直接调节 WNT 信号通路至少两个组件的转录。与协同因子 FOXP3 结合时，RUNX1:CBFB 复合物刺激 RSPO3 基因的转录，编码一种 WNT 配体，该配体被怀疑是乳腺癌致癌基因（Recouvreux et al. 2016）。与激活的雌激素受体 alpha（ESR1）结合时，RUNX1:CBFB 复合物刺激 AXIN1 的表达，AXIN1 作为 WNT 信号通路的调节因子（Stender et al. 2010）。
英文描述
RUNX1 regulates transcription of genes involved in WNT signaling The RUNX1:CBFB complex directly regulates transcription of at least two components of WNT signaling. In association with its co-factor FOXP3, the RUNX1:CBFB complex stimulates transcription of the RSPO3 gene, encoding a WNT ligand that is implicated as a breast cancer oncogene (Recouvreux et al. 2016). In association with the activated estrogen receptor alpha (ESR1), the RUNX1:CBFB complex stimulates the expression of AXIN1, which functions as a regulator of WNT signaling (Stender et al. 2010).
所含基因
6 个基因