成纤维细胞侵袭小体形成
中文名称
通路描述
成纤维细胞侵袭小体（invadopodia）是成体细胞细胞膜上基于肌动蛋白的动态突起，代表细胞与细胞外基质附着和降解的位点（Linder & Kopp 2005, Murphy & Courtneidge 2011）。它们主要由富含肌动蛋白的核心和粘附及支架蛋白组成。目前的惯例是使用“侵袭小体”一词来指代正常细胞（如单核细胞、内皮细胞和平滑肌细胞）中找到的结构，使用“侵袭小体”一词来指代癌细胞中找到的结构。侵袭小体和侵袭小体的成熟过程涉及招募和激活多种细胞周蛋白酶，促进 ECM 降解（Artym et al. 2006）。
英文描述
Invadopodia formation Podosomes and invadopodia are actin-based dynamic protrusions of the plasma membrane of metazoan cells that represent sites of attachment to and degradation of the extracellular matrix (Linder & Kopp 2005, Murphy & Courtneidge 2011). They are characteristically composed of an actin-rich core surrounded by adhesion and scaffolding proteins. Current convention is to use the term podosome for the structures found in normal cells (such as monocytic cells, endothelial cells and smooth muscle cells) and in Src-transformed fibroblasts, and invadopodium for the structures found in cancer cells. The maturation process for podosomes and invadopodia involves the recruitment and activation of multiple pericellular proteases, which facilitates ECM degradation (Artym et al. 2006).
所含基因
4 个基因