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RUNX2 regulates genes involved in differentiation of myeloid cells

Reactome ID: R-HSA-8941333

中文名称

维生素B6激活为吡哆醛磷酸

通路描述

动物无法合成吡哆醛5'-磷酸(PLP),它是氨基转移酶和其他酶的配体。PLP的可及衍生物吡哆醇、吡哆醛和吡哆胺传统上被称为维生素B6。它们从细菌和植物中营养摄取,但也由PLP在体内合成。因此,从这三种化合物回收PLP的路径也可称为维生素B6激活或PLP salvage。由于分子相似性,只需两种酶即可完成该任务(McCormick & Chen, 1999)。
英文描述
RUNX2 regulates genes involved in differentiation of myeloid cells Both RUNX2 and RUNX1 can stimulate transcription of the LGALS3 gene, encoding Galectin-3 (Vladimirova et al. 2008, Zhang et al. 2009). Galectin 3 is expressed in myeloid progenitors and its levels increase during the maturation process (Le Marer 2000). Galectin 3 is highly expressed in pituitary tumors and glioma (Vladimirova et al. 2008, Zhang et al. 2009).

所含基因

5 个基因