RUNX3 调节 CDKN1A 转录
中文名称
通路描述
RUNX3 参与 CDKN1A (p21) 基因转录的上调，以应对 TGF-beta (TGFB1) 信号通路。RUNX3 结合 SMAD3 和 SMAD4，并与激活的 SMAD3:SMAD4 复合物协同作用，促进 CDKN1A 的转录。Runx3 敲除小鼠对 TGF-beta 的敏感性降低，并出现胃上皮增生 (Chi et al. 2005)。在 TGF-beta 信号通路中，CBFB:RUNX3 复合物结合肿瘤抑制因子 ZFHX3 (ATBF1)，并通过未知机制正调控 CDKN1A 的转录 (Mabuchi et al. 2010)。此外，RUNX3 可能作为 TP53 的共激活因子，刺激 TP53 介导的靶基因转录，包括 CDKN1A (p21) (Yamada et al. 2010)。
英文描述
RUNX3 regulates CDKN1A transcription RUNX3 contributes to the upregulation of the CDKN1A (p21) gene transcription in response to TGF-beta (TGFB1) signaling. RUNX3 binds to SMAD3 and SMAD4, and cooperates with the activated SMAD3:SMAD4 complex in transactivation of CDKN1A. Runx3 knockout mice exhibit decreased sensitivity to TGF-beta and develop gastric epithelial hyperplasia (Chi et al. 2005). In response to TGF-beta signaling, the CBFB:RUNX3 complex binds to the tumor suppressor ZFHX3 (ATBF1) and, through an unknown mechanism, this complex positively regulates the CDKN1A transcription (Mabuchi et al. 2010).
In addition, RUNX3 may act as a TP53 co-factor, stimulating TP53-mediated transcription of target genes, including CDKN1A (p21) (Yamada et al. 2010).
In addition, RUNX3 may act as a TP53 co-factor, stimulating TP53-mediated transcription of target genes, including CDKN1A (p21) (Yamada et al. 2010).
所含基因
7 个基因