PTEN mRNA 翻译的调控
中文名称
通路描述
microRNA miR-17, miR-19a, miR-19b, miR-20a, miR-20b, miR-21, miR-22, miR-25, miR 26A1, miR 26A2, miR-93, miR-106a, miR-106b, miR 205 和 miR 214 结合 PTEN mRNA 并抑制其翻译为蛋白质。这些 microRNA 在癌症中发生改变，可导致 PTEN 水平的变化。有证据表明，PTEN mRNA 翻译也被其他 microRNA 抑制，如 miR-302 和 miR-26B，这些 microRNA 将在获得更多实验细节时进行注释 (Meng et al. 2007, Xiao et al. 2008, Yang et al. 2008, Huse et al. 2009, Kim et al. 2010, Poliseno, Salmena, Riccardi et al. 2010, Zhang et al. 2010, Tay et al. 2011, Qu et al. 2012, Cai et al. 2013)。此外，编码和非编码 RNA 可以阻止 microRNA 与 PTEN mRNA 结合。这些 RNA 被称为竞争性内源性 RNA 或 ceRNAs。假基因 PTENP1 的转录本以及从 SERINC1、VAPA 和 CNOT6L 基因转录的 mRNA 表现出这种活性 (Poliseno, Salmena, Zhang et al. 2010, Tay et al. 2011, Tay et al. 2014)。
英文描述
Regulation of PTEN mRNA translation MicroRNAs miR-17, miR-19a, miR-19b, miR-20a, miR-20b, miR-21, miR-22, miR-25, miR 26A1, miR 26A2, miR-93, miR-106a, miR-106b, miR 205, and miR 214 and bind PTEN mRNA and inhibit its translation into protein. These microRNAs are altered in cancer and can account for changes in PTEN levels. There is evidence that PTEN mRNA translation is also inhibited by other microRNAs, such as miR-302 and miR-26B, and these microRNAs will be annotated when additional experimental details become available (Meng et al. 2007, Xiao et al. 2008, Yang et al. 2008, Huse et al. 2009, Kim et al. 2010, Poliseno, Salmena, Riccardi et al. 2010, Zhang et al. 2010, Tay et al. 2011, Qu et al. 2012, Cai et al. 2013). In addition, coding and non coding RNAs can prevent microRNAs from binding to PTEN mRNA. These RNAs are termed competing endogenous RNAs or ceRNAs. Transcripts of the pseudogene PTENP1 and mRNAs transcribed from SERINC1, VAPA and CNOT6L genes exhibit this activity (Poliseno, Salmena, Zhang et al. 2010, Tay et al. 2011, Tay et al. 2014).
所含基因
9 个基因