PTEN 基因转录的调控

中文名称

PTEN 基因转录的调控

通路描述

PTEN 基因的转录在多个水平受到调控。表观遗传抑制涉及在 SALL4 结合到 PTEN 启动子时招募 Mi-2/NuRD 复合物（Yang et al. 2008, Lu et al. 2009），或在 EVI1 介导下招募 Polycomb 抑制复合物（PRC）到 PTEN 启动子（Song et al. 2009, Yoshimi et al. 2011）。转录调控还由负调控因子引起，包括 NR2E1:ATN1（萎缩素 -1）复合物、JUN（c-Jun）、SNAIL 和 SLUG（Zhang et al. 2006, Vasudevan et al. 2007, Escriva et al. 2008, Uygur et al. 2015），以及正调控因子如 TP53（p53）、MAF1、ATF2、EGR1 或 PPARG（Stambolic et al. 2001, Virolle et al. 2001, Patel et al. 2001, Shen et al. 2006, Li et al. 2016）。

英文描述

Regulation of PTEN gene transcription Transcription of the PTEN gene is regulated at multiple levels. Epigenetic repression involves the recruitment of Mi-2/NuRD upon SALL4 binding to the PTEN promoter (Yang et al. 2008, Lu et al. 2009) or EVI1-mediated recruitment of the polycomb repressor complex (PRC) to the PTEN promoter (Song et al. 2009, Yoshimi et al. 2011). Transcriptional regulation is also elicited by negative regulators, including NR2E1:ATN1 (atrophin-1) complex, JUN (c-Jun), SNAIL and SLUG (Zhang et al. 2006, Vasudevan et al. 2007, Escriva et al. 2008, Uygur et al. 2015) and positive regulators such as TP53 (p53), MAF1, ATF2, EGR1 or PPARG (Stambolic et al. 2001, Virolle et al. 2001, Patel et al. 2001, Shen et al. 2006, Li et al. 2016).

所含基因

59 个基因

ATF2 ATN1 BMI1 CBX2 CBX4 CBX6 CBX8 CHD3 CHD4 EED EGR1 EZH2 GATAD2A GATAD2B HDAC1 HDAC2 HDAC3 HDAC5 HDAC7 JUN KDM1A LAMTOR1 LAMTOR2 LAMTOR3 LAMTOR4 LAMTOR5 MAF1 MAPK1 MAPK3 MBD3 MECOM MLST8 MTA1 MTA2 MTA3 MTOR NR2E1 PHC1 PHC2 PHC3 PPARG RBBP4 RBBP7 RCOR1 REST RHEB RING1 RNF2 RPTOR RRAGA RRAGB RRAGC RRAGD SALL4 SLC38A9 SNAI1 SNAI2 SUZ12 TP53