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Competing endogenous RNAs (ceRNAs) regulate PTEN translation

Reactome ID: R-HSA-8948700

中文名称

竞争内源性 RNA(ceRNAs)调控 PTEN 翻译

通路描述

编码和非编码 RNA 可以阻止微 RNA 与 PTEN mRNA 结合。这些 RNA 被称为竞争内源性 RNA 或 ceRNAs。假基因 PTENP1 的转录本和从 SERINC1、VAPA 和 CNOT6L 基因转录的 mRNA 表现出这种活性(Poliseno et al. 2010, Tay et al. 2011, Tay et al. 2014)。在此上下文中,当获得额外的实验细节时,将注释 SERINC1 mRNA。
英文描述
Competing endogenous RNAs (ceRNAs) regulate PTEN translation Coding and non-coding RNAs can prevent microRNAs from binding to PTEN mRNA. These RNAs are termed competing endogenous RNAs or ceRNAs. Transcripts of the pseudogene PTENP1 and mRNAs transcribed from SERINC1, VAPA and CNOT6L genes exhibit this activity (Poliseno et al. 2010, Tay et al. 2011, Tay et al. 2014). SERINC1 mRNA will be annotated in this context when additional experimental details become available.

所含基因

8 个基因