RUNX3 调节免疫反应和细胞迁移
中文名称
通路描述
RUNX3 介导的转录调节免疫系统的发育。RUNX3 对于先天淋巴样细胞（ILCs）的发育是必需的，这些 ILCs 属于 ILC1 和 ILC3 谱系，定居在黏膜中，并参与对外部病原体的反应。RUNX3 通过刺激 RORC（RORgamma）基因的转录来发挥其在 ILC1 和 ILC3 谱系发育中的作用，该基因编码核视网膜类异源受体-γ（Ebihara 等 2015）。RUNX3 调节整合素基因 ITGAL（CD11a）和 ITGA4（CD49d）的转录，这些整合素基因参与免疫和炎症反应中白细胞穿过内皮细胞的迁移以及 T 细胞的共刺激（Domniguez-Soto 等 2005）。RUNX3 的 p33 剪接异构体缺乏 Runt 结构域，无法转激活整合素基因。p33 异构体在单核来源树突状细胞（MDDC）成熟过程中诱导，导致参与炎症反应的基因表达降低，如 IL8（白细胞介素 -8）（Puig-Kroger 等 2010）。RUNX3 正调节 SPP1（骨桥蛋白）基因的转录，这有助于胰腺癌细胞侵袭性（Whittle 等 2015）。
英文描述
RUNX3 Regulates Immune Response and Cell Migration RUNX3-mediated transcription regulates development of immune system cells. RUNX3 is necessary for the development of innate lymphoid cells (ILCs) of ILC1 and ILC3 lineages, which reside in the mucosa and are involved in response to external pathogens. RUNX3 exerts its role in the development of ILC1 and ILC3 lineages by stimulating expression of the RORC (RORgamma) gene, encoding nuclear retinoid-related orphan receptor-gamma (Ebihara et al. 2015).
RUNX3 regulates transcription of integrin genes ITGAL (CD11a) and ITGA4 (CD49d), involved in transendothelial migration of leukocytes during immune and inflammatory responses as well as co-stimulation of T cells (Domniguez-Soto et al. 2005). The RUNX3 splicing isoform p33 lacks the Runt domain and is unable to transactivate integrin genes. The p33 isoform is induced during maturation of monocyte-derived dendritic cells (MDDC), leading to reduced expression of genes involved in inflammatory responses, such as IL8 (interleukin-8) (Puig-Kroger et al. 2010).
RUNX3 positively regulates transcription of the SPP1 (osteopontin) gene, which contributes to invasiveness of pancreatic cancer cells (Whittle et al. 2015).
RUNX3 regulates transcription of integrin genes ITGAL (CD11a) and ITGA4 (CD49d), involved in transendothelial migration of leukocytes during immune and inflammatory responses as well as co-stimulation of T cells (Domniguez-Soto et al. 2005). The RUNX3 splicing isoform p33 lacks the Runt domain and is unable to transactivate integrin genes. The p33 isoform is induced during maturation of monocyte-derived dendritic cells (MDDC), leading to reduced expression of genes involved in inflammatory responses, such as IL8 (interleukin-8) (Puig-Kroger et al. 2010).
RUNX3 positively regulates transcription of the SPP1 (osteopontin) gene, which contributes to invasiveness of pancreatic cancer cells (Whittle et al. 2015).
所含基因
6 个基因