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RUNX3 regulates YAP1-mediated transcription

Reactome ID: R-HSA-8951671

中文名称

RUNX3 调节 YAP1 介导的转录

通路描述

RUNX3 与 TEADs:YAP1 复合物的结合抑制 TEADs:YAP1 加载到 CTGF 启动子的过程,从而负向调节 CTGF 基因的转录,该基因编码连接组织生长因子(Yagi 等,1999;Zhao 等,2008;Qiao 等,2016)。
英文描述
RUNX3 regulates YAP1-mediated transcription Association of RUNX3 with the TEADs:YAP1 complex inhibits loading of the TEADs:YAP1 to the CTGF promoter, thus negatively regulating transcription of the CTGF gene which encodes the Connective tissue growth factor (Yagi et al. 1999, Zhao et al. 2008, Qiao et al. 2016).

所含基因

8 个基因