RUNX3 调节 p14-ARF
中文名称
通路描述
组蛋白乙酰转移酶 p300 (EP300) 对 RUNX3 的乙酰化以及乙酰化 RUNX3 与 BRD2 的结合与 CDKN2A 位点 p14-ARF 转录的上调相关。Cyclin D1 (CCND1) 通过招募 HDAC4 到 RUNX3 上抑制 RUNX3 介导的 p14-ARF 诱导，导致 RUNX3 去乙酰化（Lee 等，2013）。
英文描述
RUNX3 regulates p14-ARF Acetylation of RUNX3 by the histone acetyl transferase p300 (EP300) and the subsequent association of acetylated RUNX3 with BRD2 correlates with upregulation of p14-ARF transcription from the CDKN2A locus. Cyclin D1 (CCND1) negatively regulates RUNX3-facilitated induction of p14-ARF by recruiting histone deacetylase HDAC4 to RUNX3, leading to RUNX3 deacetylation (Lee et al. 2013).
所含基因
9 个基因