微管羧基端翻译后修饰
中文名称
通路描述
微管蛋白折叠成紧凑的球状结构，具有较不结构化的羧基端尾部。这些尾部在不同微管蛋白异构体间序列不同，并暴露于微管表面。它们可经历多种翻译后修饰，包括聚谷氨酸链的附着和去除，以及在 alpha-微管蛋白中末端酪氨酸 (Tyr) 残基的丢失和重新附着。这些修饰与微管刚性和稳定性的变化相关 (Song & Brady 2015; Yu et al. 2015)。影响这些修饰过程的突变可能对表型产生严重影响 (例如，Ikegami et al. 2007)。然而，这些微管结构变化如何调节其功能的精确分子机制尚不清楚，因此这些修饰过程在此处简单标注为微管的化学转化系列。
英文描述
Carboxyterminal post-translational modifications of tubulin Tubulins fold into compact globular domains with less structured carboxyterminal tails. These tails vary in sequence between tubulin isoforms and are exposed on the surfaces of microtubules. They can undergo a variety of posttranslational modifications, including the attachment and removal of polyglutamate chains and in the case of alpha-tunulins the loss and reattachment of a terminal tyrosine (Tyr) residue. These modifications are associated with changes in the rigidity and stability of microtubules (Song & Brady 2015; Yu et al. 2015).
Mutations affecting these modification processes can have severe effects on phenotype (e.g., Ikegami et al. 2007). Nevertheless, the precise molecular mechanisms by which these changes in tubulin structure modulate its functions remain unclear, so these modification processes are simply annotated here as a series of chemical transformations of tubulins.
Mutations affecting these modification processes can have severe effects on phenotype (e.g., Ikegami et al. 2007). Nevertheless, the precise molecular mechanisms by which these changes in tubulin structure modulate its functions remain unclear, so these modification processes are simply annotated here as a series of chemical transformations of tubulins.
所含基因
45 个基因