活性LPL和LIPC脂酶复合物的组装
中文名称
通路描述
脂蛋白脂酶（LPL）和肝三酰甘油脂酶（LIPC）酶位于毛细血管内皮腔面，介导循环脂蛋白颗粒中甘油三酯分子的水解。
LPL在全身广泛表达，尤其在脂肪细胞和骨骼肌、心肌细胞中含量丰富。该蛋白的激活需要糖基化、二聚化和GPIHBP1（一种与高密度脂蛋白结合的糖基磷脂酰肌醇锚定蛋白）的传递，该蛋白与血浆膜上肝素硫酸蛋白聚糖（HSPG）结合。LIPC酶的成熟需要与LMF1蛋白结合（或根据序列相似性推断为LMF2）。肝素结合稳定LIPC处于其活性二聚体形式（Babilonia-Rosa & Neher 2014）。
LPL基因的转录由Cyclic AMP-responsive element-binding protein 3-like protein 3（CREB3L3）调节，该蛋白也调节APOA4、APOA5、APOC2、CIDEC和FGF21的表达（Lee et al. 2011）。
LPL在全身广泛表达，尤其在脂肪细胞和骨骼肌、心肌细胞中含量丰富。该蛋白的激活需要糖基化、二聚化和GPIHBP1（一种与高密度脂蛋白结合的糖基磷脂酰肌醇锚定蛋白）的传递，该蛋白与血浆膜上肝素硫酸蛋白聚糖（HSPG）结合。LIPC酶的成熟需要与LMF1蛋白结合（或根据序列相似性推断为LMF2）。肝素结合稳定LIPC处于其活性二聚体形式（Babilonia-Rosa & Neher 2014）。
LPL基因的转录由Cyclic AMP-responsive element-binding protein 3-like protein 3（CREB3L3）调节，该蛋白也调节APOA4、APOA5、APOC2、CIDEC和FGF21的表达（Lee et al. 2011）。
英文描述
Assembly of active LPL and LIPC lipase complexes Lipoprotein lipase (LPL) and hepatic triacylglycerol lipase (LIPC) enzymes on the lumenal surfaces of capillary endothelia mediate the hydrolysis of triglyceride molecules in circulating lipoprotein particles.
LPL is widely expressed in the body and is especially abundant in adipocytes and skeletal and cardiac myocytes. Activation of the protein requires glycosylation, dimerization, and glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1), which delivers it to heparan sulfate proteoglycan (HSPG) associated with the plasma membrane. It is inactivated by proteolytic cleavage (Berryman & Bensadoun 1995; Sukonina et al. 2006; Young et al. 2011).
Expression of the LPL gene is transcriptionally regulated by Cyclic AMP-responsive element-binding protein 3-like protein 3 (CREB3L3), which also regulates the expression of APOA4, APOA5, APOC2, CIDEC and FGF21 (Lee et al. 2011).
Maturation of LIPC enzyme requires association with LMF1 protein (or possibly, inferred from sequence similarity, LMF2). Heparin binding stabilizes LIPC in its active dimeric form (Babilonia-Rosa & Neher 2014).
LPL is widely expressed in the body and is especially abundant in adipocytes and skeletal and cardiac myocytes. Activation of the protein requires glycosylation, dimerization, and glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1), which delivers it to heparan sulfate proteoglycan (HSPG) associated with the plasma membrane. It is inactivated by proteolytic cleavage (Berryman & Bensadoun 1995; Sukonina et al. 2006; Young et al. 2011).
Expression of the LPL gene is transcriptionally regulated by Cyclic AMP-responsive element-binding protein 3-like protein 3 (CREB3L3), which also regulates the expression of APOA4, APOA5, APOC2, CIDEC and FGF21 (Lee et al. 2011).
Maturation of LIPC enzyme requires association with LMF1 protein (or possibly, inferred from sequence similarity, LMF2). Heparin binding stabilizes LIPC in its active dimeric form (Babilonia-Rosa & Neher 2014).
所含基因
19 个基因