HDL组装
中文名称
通路描述
HDL颗粒在胆固醇的逆向转运中发挥核心作用，该过程将组织以外的胆固醇返回肝脏进行胆汁酸转化和排泄，并提供给肾上腺和性腺等组织用于类固醇激素合成（Tall et al. 2008）。
HDL颗粒具有异质性，可根据其电泳迁移率、密度或所含不同apolipoproteins含量进行亚群分型（Kontush and Chapman 2006）。所有HDL颗粒共享两个关键特征：它们以apolipoprotein A-I（apoA-I）提供的蛋白质支架组装而成，并且被回收，以允许脂蛋白从外周组织流向肝脏和类固醇生成组织，同时允许apoA-I分子被重新利用。此处注释了新生（盘状）HDL颗粒在肝脏上以新合成的apoA-I组装的过程，以及通过细胞与携带过量胆固醇的相互作用将盘状HDL转化为球形HDL并装载额外脂质的过程。
HDL颗粒具有异质性，可根据其电泳迁移率、密度或所含不同apolipoproteins含量进行亚群分型（Kontush and Chapman 2006）。所有HDL颗粒共享两个关键特征：它们以apolipoprotein A-I（apoA-I）提供的蛋白质支架组装而成，并且被回收，以允许脂蛋白从外周组织流向肝脏和类固醇生成组织，同时允许apoA-I分子被重新利用。此处注释了新生（盘状）HDL颗粒在肝脏上以新合成的apoA-I组装的过程，以及通过细胞与携带过量胆固醇的相互作用将盘状HDL转化为球形HDL并装载额外脂质的过程。
英文描述
HDL assembly HDL particles play a central role in the reverse transport of cholesterol, the process by which cholesterol in tissues other than the liver is returned to the liver for conversion to bile salts and excretion from the body and provided to tissues such as the adrenals and gonads for steroid hormone synthesis (Tall et al. 2008).
HDL particles are heterogeneous and can be fractionated into sub-populations based on their electrophoretic mobility, their density, or their content of various apolipoproteins (Kontush and Chapman 2006). All HDL particles share two key features: they are assembled on a protein scaffold provided by apolipoprotein A-I (apoA-I), and they are recycled to allow a net flow of lipids from peripheral tissues to the liver and steroidogenic tissues while allowing apoA-I molecules to be re-used.
Here, the assembly of nascent (discoidal) HDL particles on newly synthesized apoA-I, a process that in the body occurs primarily in the liver, and the loading of discoidal HDL with additional lipid through interaction with cells carrying excess cholesterol (transformation to spherical HDL) are annotated.
HDL particles are heterogeneous and can be fractionated into sub-populations based on their electrophoretic mobility, their density, or their content of various apolipoproteins (Kontush and Chapman 2006). All HDL particles share two key features: they are assembled on a protein scaffold provided by apolipoprotein A-I (apoA-I), and they are recycled to allow a net flow of lipids from peripheral tissues to the liver and steroidogenic tissues while allowing apoA-I molecules to be re-used.
Here, the assembly of nascent (discoidal) HDL particles on newly synthesized apoA-I, a process that in the body occurs primarily in the liver, and the loading of discoidal HDL with additional lipid through interaction with cells carrying excess cholesterol (transformation to spherical HDL) are annotated.
所含基因
7 个基因