乳糜微粒重塑
中文名称
通路描述
乳糜微粒在体内循环时，会获得apolipoproteins C和E分子，并通过与内皮脂酶的相互作用，可以失去大量甘油三酯。这些变化将它们转化为乳糜微粒残粒，残粒主要结合到肝细胞表面的LDL受体上，从而清除它们从循环中。这一系列事件进行得很快：乳糜微粒的正常寿命为30-60分钟（Redgrave 2004）。
英文描述
Chylomicron remodeling As chylomicrons circulate in the body, they acquire molecules of apolipoproteins C and E, and through interaction with endothelial lipases can lose a large fraction of their triacylglycerol. These changes convert them to chylomicron remnants which bind to LDL receptors, primarily on the surfaces of liver cells, clearing them from the circulation. This whole sequence of events is rapid: the normal lifespan of a chylomicron is 30 - 60 minutes (Redgrave 2004).
所含基因
10 个基因