乳糜微粒清除
中文名称
通路描述
循环乳糜微粒获得apolipoproteins C和E分子，并通过与内皮脂酶的相互作用失去大量甘油三酯。这些变化将它们转化为乳糜微粒残粒，残粒主要结合到肝细胞表面的LDL受体上，从而清除它们从循环中。这一结合和清除过程涉及多个步骤，需要肝素硫酸蛋白聚糖（HSPG）相关肝脂酶（HL）的存在。LDLR结合、以及后续残粒内吞过程的分子细节，是从LDLR介导的低密度脂蛋白（LDL）内吞过程的相应步骤推断出来的（Redgrave 2004）。
英文描述
Chylomicron clearance Circulating chylomicrons acquire molecules of apolipoproteins C and E and through interaction with endothelial lipases lose a large fraction of their triacylglycerol. These changes convert them to chylomicron remnants which bind to LDL receptors, primarily on the surfaces of liver cells, clearing them from the circulation.
This binding and clearance process involves several steps and requires the presence of heparan sulfate proteoglycan (HSPG)-associated hepatic lipase (HL). The molecular details of LDLR binding, and of the following steps of remnant endocytosis, are inferred from those of the coorresponding step of LDLR-mediated low-density lipoprotein (LDL) endocytosis (Redgrave 2004).
This binding and clearance process involves several steps and requires the presence of heparan sulfate proteoglycan (HSPG)-associated hepatic lipase (HL). The molecular details of LDLR binding, and of the following steps of remnant endocytosis, are inferred from those of the coorresponding step of LDLR-mediated low-density lipoprotein (LDL) endocytosis (Redgrave 2004).
所含基因
5 个基因