LDL清除
中文名称
通路描述
LDL（低密度脂蛋白）是单分子apolipoprotein B-100（apoB-100）非共价结合甘油三酯、游离胆固醇、胆固醇酯和磷脂的复合物。LDL从血液中清除涉及与细胞表面包被小窝上的LDL受体结合，形成复合物并通过氯酪蛋白包被的小泡内吞，然后进入内体，在那里解离。LDL粒子进入溶酶体并被降解，而LDL受体则返回细胞表面。该过程发生在大多数细胞类型中，但在肝细胞中尤为显著。它在将外周组织的胆固醇返回肝脏方面起着主要作用（Hobbs et al. 1990）。
英文描述
LDL clearance LDL (low-density lipoproteins) are complexes of a single molecule of apoprotein B-100 (apoB-100) non-covalently associated with triacylglycerol, free cholesterol, cholesterol esters, and phospholipids.Clearance of LDL from the blood involves binding to LDL receptors associated with coated pits at the cell surface, forming complexes that are internalized and passed via clathrin-coated vesicles to endosomes, where they dissociate. The LDL particles move into lysosomes and are degraded while the LDL receptors are returned to the cell surface. This process occurs in most cell types but is especially prominent in hepatocytes. It plays a major role in returning cholesterol from peripheral tissues to the liver (Hobbs et al. 1990).
所含基因
19 个基因