LDL重塑
中文名称
通路描述
LDL（低密度脂蛋白）是单分子apolipoprotein B-100（apoB-100）非共价结合甘油三酯、游离胆固醇、胆固醇酯和磷脂的复合物。胆固醇酯转移蛋白（CETP）与胆固醇酯结合，与LDL（低密度脂蛋白）粒子结合，获得甘油三酯分子并捐赠胆固醇酯给LDL（Swenson et al. 1988; Morton & Zilversmit 1983），这是组织胆固醇向肝脏运输的关键步骤。作为LDLR介导的摄取和降解的替代，LDL粒子可以结合单分子LPA（apolipoprotein A），形成Lp(a)脂蛋白粒子（Lobentanz et al. 1998）。
英文描述
LDL remodeling LDL (low density lipoproteins) are complexes of a single molecule of apoprotein B-100 (apoB-100) non-covalently associated with triacylglycerol, free cholesterol, cholesterol esters, and phospholipids. CETP (cholesterol ester transfer protein) complexed with cholesterol esters interacts with an LDL (low density lipoprotein) particle, acquiring triacylglycerol molecules and donating cholesterol ester to the LDL (Swenson et al. 1988; Morton & Zilversmit 1983), a key step in the transport of tissue cholesterol to the liver.
As an alternative to LDLR-mediated uptake and degradation, a LDL particle can bind a single molecule of LPA (apolipoprotein A), forming a Lp(a) lipoprotein particle (Lobentanz et al. 1998).
As an alternative to LDLR-mediated uptake and degradation, a LDL particle can bind a single molecule of LPA (apolipoprotein A), forming a Lp(a) lipoprotein particle (Lobentanz et al. 1998).
所含基因
6 个基因