G beta:gamma 信号通过 BTK
中文名称
通路描述
G 蛋白偶联受体（GPCR）感知细胞外信号并激活具有 alpha、beta 和 gamma 亚基的不同 G 蛋白。激活后，G 蛋白的 alpha 亚基与 beta-gamma 分离，两者均游离以调节下游效应子。G 蛋白 beta-gamma 复合物与磷脂酰肌醇 3,4,5-三磷酸（PIP3）招募非受体酪氨酸蛋白激酶 BTK 至细胞膜。在此，G 蛋白 beta-gamma 复合物激活 BTK。随后，活性 BTK 从复合物中解离并磷酸化下游底物。生理上，BTK 在 B 淋巴细胞发育、分化和信号传导中发挥关键作用。
英文描述
G beta:gamma signalling through BTK G-Protein Coupled Receptors (GPCR) sense extracellular signals and activate different Guanine nucleotide binding proteins (G-proteins) that have alpha, beta and gamma subunits. Upon activation, the alpha subunit of G-proteins dissociates from beta-gamma and the both are then free to regulate downstream effectors. G-protein beta-gamma complex, along with phosphatidylinositol 3,4,5-trisphosphate (PIP3), recruits the non-receptor Tyrosine-protein kinase BTK to the cell membrane. Here, the G-protein beta-gamma complex activates BTK. Subsequently, active BTK dissociates from the complex to phosphorylate downstream substrates. Physiologically, BTK plays a key role in B lymphocyte development, differentiation and signalling.
所含基因
18 个基因