G beta:gamma 信号通过 CDC42
中文名称
通路描述
G 蛋白偶联受体（GPCR）感知细胞外信号并激活具有α、β和γ亚基的不同鸟苷酸结合蛋白（G 蛋白）。在激活后，G 蛋白α亚基从β-γ分离，两者随后自由调节下游效应分子。丝氨酸/苏氨酸蛋白激酶 PAK 1 与细胞质中的 Rho 鸟苷酸交换因子 6（ARHGEF6, PIX-Alpha）结合，随后由 G 蛋白β-γ复合物转运至细胞膜。在此，ARHGEF6 通过作为 GEF 激活 Cell division control protein 42 homolog（CDC42）。一旦激活，CDC42 可以促进 PAK1 的激活。CDC42 已知参与上皮细胞极化过程。
英文描述
G beta:gamma signalling through CDC42 G-Protein Coupled Receptors (GPCR) sense extracellular signals and activate different Guanine nucleotide binding proteins (G-proteins) that have alpha, beta and gamma subunits. Upon activation, the alpha subunit of G-proteins dissociates from beta-gamma and the both are then free to regulate downstream effectors. Serine/threonine-protein kinase PAK 1 binds with Rho guanine nucleotide exchange factor 6 (ARHGEF6, PIX-Alpha) in the cytosol and is subsequently translocated by the G-protein beta-gamma complex to the plasma membrane. Here, ARHGEF6 activates Cell division control protein 42 homolog (CDC42) by acting as a GEF. Once active, CDC42 can facilitate the activation of PAK1. CDC42 is known to be involved in epithelial cell polarization processes.
所含基因
20 个基因