RHOA GTP 酶循环

中文名称

RHOA GTP 酶循环

通路描述

该途径列出了 RHOA 鸟苷酸交换因子（GEFs）、GTP 酶激活蛋白（GAPs）、GDP 解离抑制剂（GDIs）和 RHOA 效应分子。RHOA 是三种最好研究的 RHO GTP 酶之一，另外两种是 RAC1 和 CDC42，是 RHO GTP 酶家族的奠基成员（Zhou and Zheng 2013）。RHOA 调节细胞骨架和细胞收缩性（Lessey et al. 2012），从而在多种细胞功能中发挥作用，如粘附、迁移、生存、分裂、囊泡运输和基因表达（Zhou and Zheng 2013）。RHOA 调节的过程涉及机械转导（Lessey et al. 2012; Marjoram et al. 2014）、神经发生（Zhou and Zheng 2013; Fujita and Yamashita 2014; Hu and Selzer 2017）、免疫系统发育（Zhou and Zheng 2013; Ricker et al. 2016; Bros et al. 2019）和心血管调节（Zhou and Zheng 2013; Cai et al. 2016; Shimokawa et al. 2016）。RHOA 突变在癌症中频繁发现（Kataoka and Ogawa 2016）。多种病原体的毒素靶向 RHOA 以劫持宿主细胞骨架（Jamilloux et al. 2018）。

英文描述

RHOA GTPase cycle This pathway catalogues RHOA guanine nucleotide exchange factors (GEFs), GTPase activator proteins (GAPs), GDP dissociation inhibitors (GDIs) and RHOA effectors. RHOA is one of the three best characterized RHO GTPases, the other two being RAC1 and CDC42, and is the founding member of the RHO GTPase family (Zhou and Zheng 2013). RHOA regulates the cytoskeleton and cell contractility (Lessey et al. 2012), thus playing a role in a number of cellular functions, such as adhesion, migration, survival, division, vesicle trafficking and gene expression (Zhou and Zheng 2013). RHOA-regulated processes are involved in mechanotransduction (Lessey et al. 2012; Marjoram et al. 2014), neuronal development (Zhou and Zheng 2013; Fujita and Yamashita 2014; Hu and Selzer 2017), immune system development (Zhou and Zheng 2013; Ricker et al. 2016; Bros et al. 2019), and cardiovascular regulation (Zhou and Zheng 2013; Cai et al. 2016; Shimokawa et al. 2016). RHOA mutations are frequently found in cancer (Kataoka and Ogawa 2016). Toxins of numerous pathogens target RHOA to hijack the host cytoskeleton (Jamilloux et al. 2018).

所含基因

148 个基因

AAAS ABCD3 ABR ACBD5 ACTC1 AKAP13 ANLN ARAP1 ARAP2 ARAP3 ARHGAP1 ARHGAP10 ARHGAP11A ARHGAP11B ARHGAP18 ARHGAP19 ARHGAP20 ARHGAP21 ARHGAP22 ARHGAP23 ARHGAP24 ARHGAP26 ARHGAP28 ARHGAP29 ARHGAP30 ARHGAP31 ARHGAP32 ARHGAP35 ARHGAP39 ARHGAP4 ARHGAP40 ARHGAP42 ARHGAP44 ARHGAP5 ARHGAP6 ARHGAP8 ARHGAP9 ARHGDIA ARHGDIB ARHGEF1 ARHGEF10 ARHGEF10L ARHGEF11 ARHGEF12 ARHGEF15 ARHGEF17 ARHGEF18 ARHGEF19 ARHGEF2 ARHGEF25 ARHGEF28 ARHGEF3 ARHGEF4 ARHGEF40 ARHGEF5 ARHGEF7 ATP6AP1 BCAP31 BCR C1QBP CAV1 CAVIN1 CCDC115 CIT DAAM1 DDRGK1 DEF6 DEPDC1B DIAPH1 DIAPH3 DLC1 DOCK2 ECT2 EMC3 ERBIN FAF2 FAM13A FARP1 FLOT1 FLOT2 FMNL3 GMIP HMHA1 HMOX2 IQGAP1 IQGAP3 JUP KALRN KTN1 LBR LMAN1 MACO1 MCAM MCF2 MCF2L MYO9A MYO9B NET1 NGEF OBSCN OPHN1 PCDH7 PGRMC2 PIK3R1 PIK3R2 PKN1 PKN2 PKN3 PLD1 PLEKHG3 PLEKHG4 PLEKHG5 PLEKHG6 PREX1 PREX2 RACGAP1 RASGRF2 RHOA RHPN1 RHPN2 ROCK1 ROCK2 RTKN SCFD1 SLK SNAP23 SOWAHC SRGAP1 STARD13 STARD8 STBD1 STK10 STOM STX5 TAGAP TEX2 TFRC TIAM1 TJP2 TMEM87A TMPO TRIO VAMP3 VANGL1 VAPB VAV1 VAV2 VAV3