白细胞介素 -37 信号
中文名称
通路描述
白细胞介素（IL）是免疫调节蛋白，能在细胞和组织中引发广泛的反应。白细胞介素 -37（IL37），也称为 IL1F7，是 IL1 家族的成员（Sharma et al. 2008）。IL37 的 b 等位基因（仅称为 IL37）以前体形式合成，需要加工（主要由 caspase 1 进行）才能获得完整的受体激动剂或拮抗剂功能（Kumar et al. 2002）。全长 IL37 和加工后的 IL37 均可与 IL18 结合蛋白（IL18BP）和 IL18 受体 1（IL18R1）结合（Shi et al. 2003）。当 IL37 结合 IL18R1 时，会招募单 Ig IL1 相关受体（SIGIRR）（Nold-Petry et al. 2015）。IL37:IL18R1 复合物可以激活信号转导和激活转录因子 3（STAT3）、酪氨酸蛋白激酶 Mer 和磷脂酰肌醇 3,4,5 三磷酸 3 磷酸酶以及双特异性蛋白磷酸酶 PTEN 的磷酸化，并可以抑制核因子 NF kappa B p105 亚基（NFKB）（Nold-Petry et al. 2015）。加工后的 IL37 可从细胞质分泌到细胞外空间或转运到细胞核（Bulau et al. 2014）。全长 IL37 也可从细胞质分泌到细胞外空间（Bulau et al. 2014）。加工后的 IL37 可与细胞质中的 Mothers against decapentaplegic homolog 3（SMAD3）结合，然后转运到细胞核，其中促进 PTPNs（酪氨酸蛋白磷酸酶非受体）的转录（Nold et al. 2010, Luo et al. 2017）。这些事件最终导致几种免疫细胞的细胞因子产生受到抑制，从而减少炎症。
英文描述
Interleukin-37 signaling Interleukins (IL) are immunomodulatory proteins that elicit a wide array of responses in cells and tissues. Interleukin 37 (IL37), also known as IL 1F7, is a member of the IL 1 family (Sharma et al. 2008). Isoform b of IL37 (referred just as IL37) is synthesized as a precursor that requires processing (primarily by caspase 1) to attain full receptor agonist or antagonist function (Kumar et al. 2002). Both full length and processed IL37 can bind to the IL 18 binding protein (IL 18BP) and the Interleukin 18 receptor 1 (IL 18R1) (Shi et al. 2003). Upon binding to the IL18R1, IL37 recruits Single Ig IL 1 related receptor (SIGIRR) (Nold-Petry et al. 2015). The IL37:IL18R1 complex can activate phosphorylation of Signal transducer and activator of transcription 3 (STAT3), Tyrosine protein kinase Mer and Phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase and dual specificity protein phosphatase PTEN and can also inhibit Nuclear factor NF kappa B p105 subunit (NFKB) (Nold-Petry et al. 2015). Processed IL37 can be secreted from the cytosol to the extracellular space or translocated into the nucleus (Bulau et al. 2014). Full length IL37 can also be secreted from the cytosol to the extracellular space (Bulau et al. 2014). Processed IL37 can bind with Mothers against decapentaplegic homolog 3 (SMAD3) in the cytosol and then translocate to the nucleus, where it facilitates transcription of Tyrosine protein phosphatase non receptors (PTPNs) (Nold et al. 2010, Luo et al. 2017). These events ultimately lead to suppression of cytokine production in several types of immune cells resulting in reduced inflammation.
所含基因
21 个基因