Caspase 8 在配体存在下通过死亡受体激活

中文名称

通路描述

Caspase-8 以前体形式（前 Caspase-8）合成，并通过 Caspase-8 前体作为切割产物形成。然而，切割本身似乎不足以形成活性 Caspase-8。只有前 Caspase-8 的协同二聚化和切割才能在体外产生高效激活，并在细胞系统中产生凋亡 [Boatright KM 和 Salvesen GS 2003; Keller N 等人 2010; Oberst A 等人 2010]。Caspase-8 前体在细胞中以无活性的单体形式存在，通过与 FADD 的 DED 域的同源相互作用被招募至死亡诱导信号复合物（DISC）。单体前体发生二聚化，随后在受体复合物中发生构象变化，从而形成具有催化活性的前 Caspase-8。[Boatright KM 等人 2003; Donepudi M 等人 2003; Keller N 等人 2010; Oberst A 等人 2010]。

英文描述

RAC2 GTPase cycle This pathway catalogues RAC2 guanine nucleotide exchange factors (GEFs), GTPase activator proteins (GAPs), GDP dissociation inhibitors (GDIs) and RAC2 effectors. RAC2 is exclusively expressed in hematopoietic cells (Troeger and Williams 2013). RAC2 is a component of the phagocytic oxidase complex in neutrophils (Troeger and Williams 2013). RAC2 is required for adhesion and mobilization of hematopoietic stem cells and progenitor cells (Troeger and Williams 2013). RAC2 is also needed for adhesion, migration and degranulation of mast cells (Troeger and Williams 2013). Mutations in RAC2 have been found in a small number of patients with primary immunodeficiencies (Gu and Williams 2002; Troeger and Williams 2013; Lougaris et al. 2020).

所含基因

88 个基因

ABI1 ABI2 ABR ANKLE2 ARHGAP1 ARHGAP17 ARHGAP21 ARHGAP26 ARHGAP32 ARHGAP35 ARHGAP39 ARHGAP42 ARHGDIA ARMCX3 BAIAP2L1 BCR BRK1 CAV1 CDC42 CDC42EP1 CDC42EP4 CYBA CYBB CYFIP1 DEF6 DEPDC1B DIAPH3 DOCK1 DOCK10 DOCK2 DOCK3 DOCK4 DSG2 EMD EPHA2 ERBIN ESYT1 GIT1 GIT2 IQGAP1 ITGB1 KIAA0355 LAMTOR1 LBR LEMD3 LMAN1 MCAM MCF2 MPP7 MTX1 NCF1 NCF2 NCF4 NCKAP1 NCKAP1L NHS OPHN1 PAK1 PAK2 PAK4 PGRMC2 PIK3CA PIK3R1 PIK3R2 PIK3R3 PLD2 PREX1 RAB7A RAC2 RACGAP1 SAMM50 SLITRK5 STBD1 SWAP70 SYDE1 TAOK3 TFRC TIAM1 TMPO TRIO VAMP3 VANGL1 VAPB VAV1 VAV2 VAV3 VRK2 WASF2