RHOD GTPase cycle

RHOD GTPase cycle This pathway catalogues RHOD GTPase activator proteins (GAPs) and RHOD effectors. RHOD possesses GTPase activity and is therefore grouped with classical RHO GTPases but it is atypical in the sense that no known guanine nucleotide exchange factors (GEFs) and no GDP dissociation inhibitors (GDIs) (Blom et al. 2017) are involved in the regulation of RHOD activity. RHOD possesses an elevated intrinsic guanine nucleotide exchange activity and auto-activates (Jaiswal, Fansa et al. 2013). RHOD regulates cytoskeletal dynamics and intracellular transport of vesicles (Gad and Aspenstrom 2010; Aspenstrom et al. 2014), especially actin-dependent movement of endosomes (Gasman et al. 2003, reviewed in Randazzo 2003).