RHOG GTPase 循环

中文名称

RHOG GTPase 循环

通路描述

该通路收录了 RHOG 的鸟苷酸交换因子 (GEFs)、GTP 酶激活蛋白 (GAPs)、GDP 解离抑制剂 (GDIs) 和 RHOG 效应子。RHOG 是一种与 RAC 相关的 RHO GTP 酶，约 70% 与 RAC1 相似 (Vincent et al. 1992, de Curtis 2008)。RHOG 在各种组织类型中广泛表达。它调节细胞骨架，作用机制是在 RAC1 上游或与其平行。RHOG 调节细胞极性、粘附、迁移和侵袭，有助于形成伪足和侵袭伪足 (Gauthier-Rouvière et al. 1998, Al-Koussa et al. 2020)。RHOG 的直系同源物对于秀丽隐杆线虫的神经发育是必需的 (de Curtis 2008)。RHOG 参与 VEGF 信号传导和血管生成 (El Baba et al. 2020)。RHOG 与 RAC1 和 CDC42 合作参与恶性细胞转化 (Roux et al. 1997)，并可能促进癌细胞的侵袭性 (Al-Koussa et al. 2020)。

英文描述

RHOG GTPase cycle This pathway catalogues RHOG guanine nucleotide exchange factors (GEFs), GTPase activator proteins (GAPs), GDP dissociation inhibitors (GDIs) and RHOG effectors. RHOG is a RAC-related RHO GTPase, ~70% identical to RAC1 (Vincent et al. 1992, de Curtis 2008). RHOG is broadly expressed in different tissue types. It regulates the cytoskeleton, acting either upstream of or in parallel to RAC1. RHOG regulates cell polarity, adhesion, migration and invasion, contributing to the formation of lamellipodia and invadopodia (Gauthier-RouviÃ¨re et al. 1998, Al-Koussa et al. 2020). The ortholog of RHOG is required for neuronal development in C. elegans (de Curtis 2008). RHOG is involved in VEGF signaling and angiogenesis (El Baba et al. 2020). RHOG cooperates with RAC1 and CDC42 in malignant cell transformation (Roux et al. 1997) and may contribute to invasiveness of cancer cells (Al-Koussa et al. 2020).

所含基因

73 个基因

ANKLE2 ARFGAP3 ARHGAP1 ARHGAP21 ARHGAP32 ARHGAP35 ARHGAP39 ARHGAP5 ARHGDIA ARHGDIB ARHGDIG ARHGEF16 ARHGEF26 ARHGEF5 CAV1 CDC42 CDC42EP1 CYFIP1 DEPDC1B DIAPH3 DOCK1 DOCK2 DOCK3 DOCK4 DOCK5 DSG2 ELMO2 EMD EPHA2 ERBIN ESYT1 HSPE1 IQGAP2 ITGB1 ITSN1 KALRN KIAA0355 KTN1 LAMTOR1 LBR LEMD3 LETM1 LMAN1 MAP3K11 MCAM MCF2 MCF2L MPP7 NDUFA5 NDUFS3 OPHN1 PAK2 PAK4 PGRMC2 PIK3R1 PLD1 PLEKHG3 PREX1 RAB7A RHOG SHMT2 STBD1 STX5 TFRC TMPO TRIO VAMP3 VANGL1 VAPB VAV1 VAV2 VAV3 VRK2