RHOJ GTPase 循环

中文名称

RHOJ GTPase 循环

通路描述

该通路收录了 RHOJ (也称为 TCL 或 RHOI) 的鸟苷酸交换因子 (GEFs)、GTP 酶激活蛋白 (GAPs) 和 RHOJ 效应子。尚未发现与 RHOJ 相互作用的 GDP 解离抑制剂 (GDIs)。RHOJ 与 RHOQ (TC10) 一起属于 RHO GTP 酶的 CDC42 亚家族，分别与 RHOQ 和 CDC42 具有 85% 和 78% 的氨基酸相似性 (Vignal et al. 2000)。RHOJ 调节细胞骨架，包括伪足和微丝的形成 (Vignal et al. 2000, Abe et al. 2003, Aspenstrom et al. 2004, Shi et al. 2016)。RHOJ 在血管内皮细胞中高度表达，调节其运动性，从而调控血管形态发生 (Leszczynska et al. 2011; Shi et al. 2016)。作为 VEGF 信号传导途径的一部分，RHOJ 促进视网膜血管生成 (Fukushima et al. 2013)。RHOJ 参与癌细胞的迁移和与癌症相关的血管生成 (Shi et al. 2016)。RHOJ 参与脂肪细胞分化 (Nishizuka 2003; Shi et al. 2016)。

英文描述

RHOJ GTPase cycle This pathway catalogues RHOJ (also known as TCL or RHOI) guanine nucleotide exchange factors (GEFs), GTPase activator proteins (GAPs), and RHOJ effectors. No GDP dissociation inhibitors (GDIs) have been shown to interact with RHOJ. RHOJ, together with RHOQ (TC10), belongs to the CDC42 subfamily of RHO GTPases and shares 85% and 78% amino acid similarity with RHOQ and CDC42, respectively (Vignal et al. 2000). RHOJ regulates the cytoskeleton, including formation of lamellipodia and actin filaments (Vignal et al. 2000, Abe et al. 2003, Aspenstrom et al. 2004, Shi et al. 2016). RHOJ is highly expressed in endothelial cells, regulating their motility and, consequently, vascular morphogenesis (Leszczynska et al. 2011; Shi et al. 2016). As a part of the VEGF signaling cascade, RHOJ promotes retinal angiogenesis (Fukushima et al. 2013). RHOJ plays a role in cancer cell migration and cancer-related angiogenesis (Shi et al. 2016). RHOJ is involved in adipocyte differentiation (Nishizuka 2003; Shi et al. 2016).

所含基因

55 个基因

ARHGAP1 ARHGAP21 ARHGAP26 ARHGAP32 ARHGAP35 ARHGAP5 ARHGEF7 ARL13B CAV1 CDC42 CDC42BPA CDC42BPB CDC42EP1 CPNE8 DEPDC1B DIAPH3 DOCK8 FMNL3 FNBP1 FNBP1L GIT1 GIT2 GJA1 IQGAP3 JUP LAMTOR1 MPP7 NIPSNAP2 OCRL OPHN1 PAK1 PAK2 PAK3 PAK4 PIK3R1 PIK3R2 PREX1 RAB7A RHOJ SCRIB SLC1A5 SLC4A7 SNAP23 STEAP3 STOM SYDE1 TFRC TMPO TRIO VAMP3 VANGL1 WAS WASP WIPF2 WWP2