RHOU GTPase 循环
中文名称
通路描述
RHO GTP 酶 RHOU (Wrch-1) 具有内在的高鸟苷酸交换活性，并且在没有鸟苷酸交换因子 (GEFs) 的情况下始终处于 GTP 结合状态 (Shutes et al. 2004, Saras et al. 2004)。RHOU 不具有 GTP 酶活性 (Saras et al. 2004)。据报道，RHOU 与一些 GTP 酶激活蛋白 (GAPs) 相互作用，这些可能作为效应子，使其他 RHO GTP 酶之间的交叉通讯成为可能。RHOU 被证明调节细胞骨架动力学、细胞迁移和粘附。RHOU 在胚胎发育期间表达，并调节心脏 (Dickover et al. 2014) 和肠道 (Slaymi et al. 2019) 发育。RHOU 在细胞迁移期间激活 JNK 和 AKT 信号传导 (Chuang et al. 2007)。
英文描述
RHOU GTPase cycle RHO GTPase RHOU (Wrch-1) possesses a high intrinsic guanine nucleotide exchange activity and is constitutively present in the active GTP-bound state in the absence of guanine nucleotide exchange factors (GEFs) (Shutes et al. 2004, Saras et al. 2004). RHOU does not possess a GTPase activity (Saras et al. 2004). RHOU has been reported to interact with some GTPase activator proteins (GAPs) (Bagci et al. 2020), which may serve as effectors that enable cross-talk with other RHO GTPases. RHOU was shown to regulate cytoskeletal dynamics, cell migration and adhesion. RHOU is expressed during embryonic development and regulates cardiac (Dickover et al. 2014) and intestinal (Slaymi et al. 2019) development. RHOU activates JNK and AKT signaling during cell migration (Chuang et al. 2007).
For review, please refer to Faure and Fort 2015, and Hodge and Ridley 2020.
For review, please refer to Faure and Fort 2015, and Hodge and Ridley 2020.
所含基因
39 个基因