Interleukin-36 pathway
中文名称
通路描述
IL36α(IL36A)、IL36B 和 IL36G 统称为 IL36。它们是 Interlukin-1 家族的成员，通过由 Interleukin-1 受体类似蛋白 2(IL1RL2, IL36R) 和 Interleukin-1 受体辅助蛋白(IL1RAP, IL-1R/AcP) 组成的受体信号转导，促进炎症反应。IL36RN(IL36Ra) 是天然的拮抗剂。IL36 主要在上皮细胞中表达，并通过功能和遗传证据在银屑病疾病的病理中起强烈作用。
英文描述
Interleukin-36 pathway Interleukin-36 alpha (IL36A), IL36B and IL36G are collectively known as IL36. They are members of the Interlukin-1 family that signal through a receptor composed of Interleukin-1 receptor-like 2 (IL1RL2, IL36R) and Interleukin-1 receptor accessory protein (IL1RAP, IL-1R/AcP) to promote inflammatory responses. Interleukin-36 receptor antagonist protein (IL36RN, IL36Ra) is a natural antagonist. IL36 is expressed predominantly by epithelial cells and is implicated strongly through functional and genetic evidence in the pathology of psoriatic disorders.
所含基因
6 个基因