Noncanonical activation of NOTCH3
中文名称
通路描述
除了 DLL/JAG 配体外，NOTCH3 信号也可以通过 NOTCH3 与 YBX1(YB 1) 的结合而被激活(Rauen et al. 2009)。YBX1 是一种参与 mRNA 加工蛋白，在炎症期间由肾小球细胞和单核细胞分泌，作为细胞外细胞因子(Frye et al. 2009)。YBX1 触发γ分泌酶复合物介导的 NOTCH3 切割，释放 NOTCH3 细胞内域(NICD3) 并激活 NOTCH3 靶基因(Rauen et al. 2009)。
英文描述
Noncanonical activation of NOTCH3 Besides DLL/JAG ligands, NOTCH3 signaling can also be activated by binding of NOTCH3 to YBX1 (YB 1) (Rauen et al. 2009). YBX1, a protein involved in mRNA processing, is secreted by mesangial cells and monocytes during inflammation and acts as an extracellular mitogen (Frye et al. 2009). YBX1 triggers the gamma secretase complex mediated cleavage of NOTCH3, resulting in release of NOTCH3 intracellular domain (NICD3) and activation of NOTCH3 target genes (Rauen et al. 2009).
所含基因
9 个基因