DHA 衍生的 SPMs 的生物合成
中文名称
通路描述
花生四烯酸 (DHA) 是鱼类油中主要的 Ï-3 多不饱和脂肪酸 (PUFA)，是 D 系列 resolvins (RvDs) 的来源之一，后者是一类具有强大抗炎和促修复作用的特化促炎介质 (SPMs) (Molfino et al. 2017)。RvDs 的生物合成主要发生在炎症过程中，当内皮细胞与白细胞相互作用时发生。膳食 DHA 在血浆中循环或在细胞膜中存在，因为它可以轻易整合到膜中。在损伤或感染时，DHA 随水肿进入急性炎症的局部组织部位，在那里被转化为渗出物 RvDs 以与局部免疫细胞相互作用 (Kasuga et al. 2008)。DHA 由阿司匹林乙酰化的环氧化酶 -2 或环氧化酶介导的催化初始转化可产生手性特异性的 D- resolvins (18(R)-或 18(S)-RvDs 分别)。氧化、还原和水解反应的组合决定了形成的 D- resolvin 的类型 (RvD1-6) (Serhan et al. 2002, Serhan & Petasis 2011, Serhan et al. 2014)。
英文描述
Biosynthesis of DHA-derived SPMs Docosahexaenoic acid (DHA), a major Ï-3 polyunsaturated fatty acid (PUFA) found in fish oil is the source of D-series resolvins (RvDs), one of the specialized proresolving mediators (SPMs) that show potent anti-inflammatory and pro-resolving actions (Molfino et al. 2017). The biosynthesis of RvDs occurs mainly during the process of inflammation when endothelial cells interact with leukocytes. Dietary DHA circulates in plasma or is present in cellular membranes as it can easily integrate into membranes. On injury or infection, DHA moves with edema into the tissue sites of acute inflammation where it is converted to exudate RvDs to interact with local immune cells (Kasuga et al. 2008). The initial transformation of DHA by aspirin-acetylated cyclooxygenase-2 or cyclooxygenase-mediated catalysis can produce stereospecific D-resolvins (18(R)- or 18(S)-RvDs respectively). Combinations of oxidation, reduction and hydrolysis reactions determine the type of D-resolvin formed (RvD1-6) (Serhan et al. 2002, Serhan & Petasis 2011, Serhan et al. 2014).
所含基因
3 个基因